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RR1, a patent-pending immune modulatory polysaccharide derived from Tinospora cordifolia


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Summary of claims: RR1 is a novel α-D-glucan polysaccharide composed of a (1→4) linked back bone and (1→6) linked branches.  RR1 exhibits unique immune-stimulating properties and is non-cytotoxic.  The subject invention also concerns compositions containing an RR1 compound and methods for modulating an immune response in a subject using RR1 compounds.


Nair PKR, Rodriguez S, Ramachandran R, Alamo A, Melnick, SJ, Escalon E, Garcia PI, Wnuk SF, Ramachandran, C. Immune stimulating properties of a novel polysaccharide from the  medicinal plant Tinospora cordifolia. International Immunopharmacology. 2004;4:1645-1659.


Nair, PKR,  Melnick SJ, Ramachandran R; Escalon E, Ramachandran C. Mechanism of Immune System Activation by (1,4)-α-D-glucan from Tinospora cordifolia. International Immunopharmacology. 2005;6:1815-1824.