Summary of claims: Amooranin (AMR) is a novel pentacyclic triterpenoid that has been found to cause tumor cell death through G₂/M cell cycle arrest, caspase activation, and apoptosis and is a substrate for P-glycoprotein.  Consequently AMR compounds can be used in the treatment of diseases where aberrant cellular proliferation occurs; drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.

Rabi T, Ramachandran C, Fonseca HB, Alamo A, Escalon E , Melnick SJ. Amooranin, a novel chemotherapeutic drug induces apoptosis through caspase activity in human breast carcinoma cell lines. Breast Cancer Research and Treatment. 2003;80:321-30.

 

Ramachandran C, Rabi T, Fonseca HB, Melnick SJ,  Escalon E. Novel plant triterpenoid drug amooranin overcomes multidrug resistance in human leukemia and colon carcinoma cell lines. Int. J. Cancer. 2003;105:784-9.

 

Ramachandran C, Nair PKR, Alamo, A, Cochrane CB, Escalon E, Melnick, SJ. Anticancer Effects of Amooranin in Human Colon Carcinoma Cell Line in vitro and in Nude Mice Xenografts. Int  J Cancer. 2007;119:2443-54.